The Midwest Roybal Center is holding a competition that will review and award up to 2 randomized controlled trials. Trials will begin June 1, 2025. Projects can be funded for up to $200K direct total for 1 or 2 years.
LOI: December 9, 2025
Final proposal due (if selected): January 20, 2025
The University of Illinois Chicago (UIC) Midwest Roybal Center for Health Promotion and Translation seeks to advance the science, translation, and practice of health promotion programs for underserved older adults at risk of Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) in order to improve the functioning and quality of life of this growing segment of our population.
Application Details:
The Midwest Roybal Center will award applications that successfully:
Include interventions that prevent or delay cognitive decline and AD/ADRD that:
Target mechanisms of behavior change to promote behavioral and lifestyle change in individuals or groups at risk of cognitive decline and AD/ADRD AND/OR
Spur the initiation and maintenance of physical activity regimens to prevent or delay cognitive decline and/or AD/ADRD that are personalized to individuals or groups who share specific characteristics and/or preferences AND/OR
Leverage technology to prevent or delay cognitive decline and/or AD/ADRD
Have a primary focus on behavioral and/or social intervention development.
Focus on mid-life and older individuals.
Have goals to improve the health and well-being of people living with dementia (PLWD), or with a focus on behavioral and/or social interventions to prevent or delay cognitive decline and/or AD/ADRD.
Specify, within their Specific Aims, the Stage of research, as defined by the NIH Stage Model, for the clinical trial proposed.
State and propose to test, within their Specific Aims, hypotheses regarding the mechanism of behavior change of interventions for the clinical trial proposed.
Have the goal of serving as inclusive a population as possible, and applicants are required to describe how they will recruit participants from minority health and health disparity populations.
Address issues of statistical power for proposed clinical trials. All clinical trials must have adequate statistical power to test mechanisms of behavior change and/or efficacy of the intervention. This includes Stage I “pilot” testing studies that include a specific aim to test the efficacy of an intervention, or the mechanism of behavior change of an intervention.
Awardees are expected to participate in Midwest Roybal Center activities pertaining to research, education, and service and will be expected to make brief presentations to the Center Executive and Advisory Committees during the course of the RCT and upon its completion. Awardees must comply with NIH and NIA reporting requirements e.g., ClincalTrials.gov and CROMS. Funded RCTs may also be required to participate in an NIH data sharing plan and in a Center Data Safety Monitoring Committee.
Eligibility:
Open to all US research and clinical faculty.
Submit LOI here (users will need to create an InfoReady account).